At this point it will serve little purpose to
become too deeply involved in the technical jargon of Memory
modules, such as Dimms, Simms, Dram and SDRam.
Suffice to say for our purposes, all ram modules fit into
memory slots on the motherboard. 486 motherboards use
either 30pin simms or 72 pin simms. Pentium motherboards
require at least 72pin simms or 168pin Dimm SDram modules.
30pin Simm

found on older 386/486 motherboards
72pin Simm

found on later 486 systems/early Pentium systems
168pin Dimm

latest version of Ram Memory, often called:
PC100 and SDRam
The ram slots are typically easy to insert and
uninstall memory. Memory modules fit in only one
direction, with the Simms note the small cut on one side of
the module, it corresponds with a tab in the memory holder.
In using Dimms, 168pin ram, they have a distinctive pattern of
three areas on the bottom of the module that must be aligned
in order for the module to fit into the holder. Once a
Dimm is in place the side clamps lock into place. This
is the same with Simm modules, the small clips that hold them
in place will lock once the module is properly installed.
On rare occasions the bottom of the module
will not make good contact with the holder. You can
remove any tarnish or other coatings that infringe upon good
contact with the eraser of a pencil or rub them with a small
amount of alcohol.
INSTALLATION OF RAM
MODULES
Simms:
When installing SIMMs, most manufacturers
require the module to be inserted at a 45 degree angle, then
"snapped" forward to the correct position. Most
Pentium systems require matched pairs of modules.
Dimms (SDRam):
Unlike SIMM installation, DIMMs may be
"snapped" directly into the socket. Some DIMM
sockets have minor physical differences. If your module
doesn't seem to fit, please do not force it into the socket...
attempt to return the module for one that fits your
motherboard.

Another issue that occurs is the use of mis-matched
ram. In the case of Pentium or better motherboards and
using Simms, the simm must be installed two at a time, matched
pairs of ram.
If in fact the memory holders on the
motherboard can become damaged or unable to properly seat
memory in rare instances. The only hope for such
problems is replacing the motherboard.